No, MacroDroid must run in background at least in order to manage all triggers used in your macrosAnother question at last.
To run a Macro Macrodroid have to run.
Is it posible to automatically avtivate Macrodroid, run the Macro and deactivate Macrodroid?
I hope you understand what I mean...
Unless there's a specific need for a widget, the Shortcut Launched trigger is simpler. You can create a shortcut by simply long-pressing on your macro then choosing Create Home Screen Shortcut...You can use the widget button trigger :
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